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A colonoscopy is an examination by your senior health care physician of the colon (large intestine) by means of a long, flexible, lighted tube inserted into the rectum and beyond. Don't fret, as most colonoscopies are performed with medical sedation to relieve any discomfort. If polyps are found, they can readily be removed during the examination procedure. Be sure to give permission to remove polyps, if discovered, before the exam.