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Unless specifically told otherwise by your senior health care physician, it is important to take medications with an 8-ounce glass of water. This amount of water eases dilution of the medications in our system, and speeds the medication process for us. Read the labels carefully - they often state 'never with milk', 'never with caffeine', 'only with.....'. Some liquids can actually counteract the effect of medication, so caution is necessary.